"Molecular Docking Study of Chlamydia Trachomatis Using Salicylidene Acylhydrazides as Inhibitors"
نویسندگان
چکیده
Emmanuel Israel Edache1,2*, Adamu Uzairu2, Paul Andrew Mamza2 and Gideon Shallangwa2 Author Affiliations 1Department of Pure Applied Chemistry, University Maiduguri, Borno State, Nigeria 2Department Ahmadu Bello University, Zaria, Received: May 25, 2021 | Published: June 23, Corresponding author: Edache, Department DOI: 10.26717/BJSTR.2021.36.005895
منابع مشابه
Molecular Dynamics and Docking Investigations of Several Zoanthamine-Type Marine Alkaloids as Matrix Metaloproteinase-1 Inhibitors
Zoanthamine-type alkaloids display a wide spectrum of biological effects. This study aimed to examine the inhibitory effects of norzoanthamine and its ten homologues of zoanthamine class on human fibroblast collagenase by modeling a three-dimensional structure of the ligands at collagenase using energy minimization, docking, molecular dynamics simulation and MM-PB/GBSA binding free energy calcu...
متن کاملSynthesis novel bis-Coumarin derivatives as potential acetylcholinestrase inhibitors: An in vitro, molecular docking, and molecular dynamics simulations study
Alzheimer's disease is an irreversible and progressive brain disorder that slowly destroys memory and thinking skills and ultimately the ability to do the simplest things and can lead to death. Cholinesterases (ChEs) play an important role in controlling cholinergic transmission, and subsequently, by inhibiting CHEs, acetylcholine levels in the brain are elevated. Coumarins have been shown to e...
متن کاملChlamydia trachomatis: Molecular Testing Methods
Screening tests to detect Chlamydia trachomatis infections have advanced to permit the detection of nucleic acids from organisms. The development of these molecular assays that can detect and amplify the specific nucleic acids from the genes of C. trachomatis are called nucleic acid amplification tests (NAATs) and they have expanded the range of available specimen types to include noninvasive s...
متن کاملSynthesis of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones as potential bioisosteres of salicylidene acylhydrazides.
A focused library of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones was prepared in a four-step synthesis with the aim to obtain potent inhibitors of type III secretion in Gram-negative bacteria. The compounds are potential bioisosteres of salicylidene acylhydrazides that are a known class of type III secretion inhibitors.
متن کاملSynthesis of 2-(2-aminopyrimidine)-2,2-difluoroethanols as potential bioisosters of salicylidene acylhydrazides.
Salicylidene acylhydrazides are inhibitors of type III secretion in several gram-negative pathogens. To further develop the salicylidene acylhydrazides, scaffold hopping was applied to replace the core fragment of the compounds. The novel 2-(2-amino-pyrimidine)-2,2-difluoroethanol scaffold was identified as a possible analog to the salicylidene acylhydrazide core structure. The synthesis of a l...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biomedical Journal of Scientific and Technical Research
سال: 2021
ISSN: ['2574-1241']
DOI: https://doi.org/10.26717/bjstr.2021.36.005895